Paracetamol treatment in high blood pressure

PAracetamol Treatment in Hypertension: effect on Blood Pressure (PATH-BP) study

David J Webb (lead researcher)

Edinburgh, University of

Start date: 01 November 2014 (Duration 3 years)

Anti-inflammatory pain killers such as ibuprofen can increase blood pressure, thereby increasing the risk of having a heart attack or stroke. People with high blood pressure are advised not to take them. One alternative is paracetamol, but it’s possible that paracetamol also increases blood pressure. It’s important to understand whether this is the case, as patients could be putting themselves more at risk of having a heart attack or stroke by continuing to take paracetamol.

This three-year trial, led by Professor David Webb, aims to answer the question of what effect paracetamol has on blood pressure. After recruiting 100 people to the trial who are already known to have high blood pressure they will be randomly split into two groups. One group will receive regular doses of paracetamol while the other group will take a placebo (dummy). All the participants will be monitored closely and blood pressure and blood samples taken regularly over two weeks. The findings could help doctors and pharmacists to advise patients with high blood pressure which pain-killers are safe to take.

Project details

Grant amount £139,908
Grant type Project Grant
Start Date 01 November 2014
Duration 3 years
Reference PG/13/26/30128
Status In progress

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