An ECG score to predict the risk of sudden death in Brugada syndrome

Novel methods for risk assessment of patients with the brugada syndrome: The Rare Arrhythmia Syndrome Evaluation (RASE) - Brugada study

Elijah Behr (lead researcher)

St George's, University of London

Start date: 01 July 2016 (Duration 3 years)

Dr Elijah Behr and his colleagues at St George’s, University of London, are developing ways to detect people with Brugada syndrome at high risk of dying suddenly from a fatal abnormal heart rhythm.

Brugada syndrome is an inherited heart condition where the heart’s electrical signals are abnormal. It mainly affects young and middle-aged men, and is diagnosed using an electrocardiogram or ECG as a record of the heart’s electrical activity. Most people with Brugada syndrome remain healthy, but some die suddenly, despite having a structurally normal heart and no warning symptoms, because they develop an abnormal heart rhythm called a ventricular arrhythmia. Currently doctors cannot identify which people with Brugada syndrome are at increased risk of ventricular arrhythmia and who should have an implantable cardioverter defibrillator (ICD) fitted to prevent fatal heart rhythms occurring.

In this project, Dr Behr will use clinical data, including genetic data, from people with Brugada syndrome, alongside computer methods of ECG analysis to identify new markers that flag those at high risk of dying suddenly. They will work closely with other academic institutions to develop a new ECG-based ‘risk score’ that helps doctors identify high risk patients.

This research could reveal new tests to predict high risk of sudden cardiac death in people with Brugada syndrome so they can receive treatments such as ICDs. These tests could also detect people with other electrical and heart muscle conditions that cause similar risks.

Project details

Grant amount £299,026
Grant type Project Grant
Start Date 01 July 2016
Duration 3 years
Reference PG/15/107/31908
Status In progress

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