Myocardial electro-architecture underlying fibrillatory conduction in complex arrhythmogenesis (renewal: years 16-20)
Professor Nicholas Peters and colleagues at Imperial College London are studying fibrillation, a heart rhythm disorder where electrical current flows through the heart muscle in an uncoordinated and irregular way. He wants to identify the processes underpinning the disease in the hope it will reveal new ways to treat it. Depending on the area of the heart affected, fibrillation can cause palpitations, stroke and sudden death. We don’t fully understand why fibrillation occurs, and scientists are currently debating whether it is a random and disorganised heart rhythm or an organised heart rhythm disorder driven by specific areas of heart muscle. In this programme, Professor Peters and his team will use a range of techniques to study the structure and function of the heart to work out how fibrillation arises and how abnormal electrical currents and heart muscle scarring contribute to it. His team will study cells in culture, isolated heart muscle, electrical recordings from the heart in people and computer simulations of abnormal heart rhythms. Understanding how fibrillation occurs in heart muscle may reveal new and better ways to prevent or treat fibrillation or new tools to select those people who should receive ablation treatments.
Project details
| Grant amount | £1,339,188 |
|---|---|
| Grant type | Chairs & Programme Grants |
| Application type | Programme Grant |
| Start Date | 01 May 2016 |
| Duration | 5 years |
| Reference | RG/16/3/32175 |
| Status | In Progress |
