Can tranexamic acid prevent or slow bleeding in the brain?

MRI evaluation of effects of tranexamic acid in spontaneous intracerebral haemorrhage: The TICH-2 MRI study

Bleeding into the brain can lead to stroke, and subsequent bleeds that continue afterwards put the patient at higher risk of death or disability. Tranexamic acid is a drug that is currently used against bleeding in acute trauma, and it also has the potential to reduce further bleeding after a stroke. Dr Robert Dineen from the University of Nottingham is conducting a trial (called TICH-2) of tranexamic acid in 2000 patients with brain bleeds. Patients with brain bleeds often develop swelling around the bleed and areas of brain damage away from the bleed due to reduced blood flow to these parts of the brain. Dr Dineen aims to find out whether tranexamic acid reduces the swelling or brain damage. He will perform a magnetic resonance imaging (MRI) scan five days and 90 days after the initial brain bleed in 280 participants who have joined the TICH-2 trial. The scans will then be used to find out if tranexamic acid affects the amount of brain swelling and damage caused by brain bleeds. They will also test whether the effect on swelling and brain damage influences how patients recover.