Metabolic markers of cardiac reverse remodelling in heart failure (Dr Peregrine Green)
This Oxford team will use innovative new techniques to understand how some failing hearts recover. Damage to the heart from many causes, including heart attacks, can lead to heart failure. This is where the heart is unable to pump well enough to meet the demands of the body. In some circumstances, the failing heart can recover if the underlying cause is treated, a process known as ‘reverse remodelling’. But not all patients’ hearts respond to treatment in this way, and scientists don’t yet understand how reverse remodelling occurs. Research has shown that the use of pacemakers to restore a heart rhythm, a treatment called cardiac resynchronisation therapy (CRT), can result in reverse remodelling. This Oxford team believe that reverse remodelling may depend on the heart’s cells being able to replenish and burn its energy sources efficiently – in other words, its ‘metabolism’. The team has developed a new way of measuring the energy efficiency of a person’s heart and plan to test this using high tech MRI scanners to look at heart metabolism in heart failure patients in real time. This study could help to explain why some people can recover from heart failure and help to identify new drugs which target cell metabolism to help restore heart function.
Project details
| Grant amount | £304,115 |
|---|---|
| Grant type | Fellowships |
| Application type | Clinical Research Training Fellowship |
| Start Date | 01 October 2018 |
| Duration | 3 years |
| Reference | FS/18/50/33807 |
| Status | In Progress |
