Mechanisms of excess risk in Aortic STEnosis after valve Replacement (MASTER)
The aortic valve controls blood flow from the heart into the body’s main artery: the aorta. Aortic stenosis is the narrowing of this valve. In severe cases, surgery is needed to replace it. Around half of people with severe aortic stenosis also have heart muscle damage known as a myocardial scar. People with this damage are twice as likely to die within a few years of having their aortic valve replaced, but the reason for this remains unclear. Dr Thomas Treibel of University College London wants to find out if the myocardial scars cause abnormal heart rhythms or reduce the heart’s ability to pump blood around the body. To achieve this, his team will monitor 192 people undergoing surgery to replace their aortic valve. . Heart scans (magnetic resonance imaging, or MRI) will be used to assess muscle damage and pumping ability. The heart’s electrical activity will be continuously monitored by a small wireless device (an insertable cardiac monitor, ICM) injected underneath the skin. This research aims to show exactly what is happening in the heart in aortic stenosis patients after valve replacement. The new knowledge could help doctors identify patients at high risk of future heart problems. Appropriate medicines and therapies could then be provided for these patients, helping to protect them from premature death.
Project details
| Grant amount | £970,683 |
|---|---|
| Grant type | Fellowships |
| Application type | Intermediate Clinical Research Fellowship |
| Start Date | 01 January 1900 |
| Duration | 5 years |
| Reference | FS/19/35/34374 |
| Status | In Progress |
