Mechanisms and reversibility of heart failure associated with diabetes: a cardiac magnetic resonance study
People with diabetes are at increased risk of developing heart failure, where the heart is unable to pump enough blood around the body. It is unknown why diabetics are prone to heart failure and which treatments can slow the progression of heart failure in diabetes. This clinical research training fellowship involves studying volunteers who have diabetes, and measuring their blood pressure, hormone levels (blood tests) and the structure and function of their heart using cardiac magnetic resonance imaging scans. People with diabetes are often treated with a drug called an ACE inhibitor to improve their kidney function. ACE inhibitors may also have a beneficial effect on their heart, and to find out if this is the case, the researchers will repeat the studies after the participants have taken this tablet for 9 months. The research will help our understanding of how diabetes causes heart failure, and will guide future treatments. If deterioration of heart function in diabetes can be prevented by treatment with an ACE inhibitor, earlier prescribing of this medication could delay the onset of heart failure.
Project details
| Grant amount | £229,631 |
|---|---|
| Grant type | Fellowships |
| Application type | Clinical Research Training Fellowship |
| Start Date | 01 March 2013 |
| Duration | 3 years |
| Reference | FS/12/88/29901 |
| Status | Complete |
