Macrophage regulation of the pro-hypertensive and pro-inflammatory effects of endothelin-1
High blood pressure (hypertension) is an important risk factor for heart disease, and its cause remains unclear in most people. Recent studies have suggested that a particular cell within the immune system, the macrophage, is involved in the development and progression of hypertension. Endothelin-1 (ET-1) is a chemical produced in the body, which raises blood pressure and causes hypertension. Dr Dhaun, who is based at the University of Edinburgh, has found that macrophages take up ET-1 and he proposes that these cells may control the effects of ET-1 on blood pressure. In this Intermediate Clinical Fellowship, he will find out how macrophages control the effects of ET-1 and whether mice still develop hypertension caused by ET-1 when macrophages are removed. Understanding how macrophages control the effects of ET-1 will provide us with a better understanding of how blood pressure is controlled. Perhaps by altering the number and functions of macrophages, we will find new approaches to treat high blood pressure.
Project details
| Grant amount | £818,264 |
|---|---|
| Grant type | Fellowships |
| Application type | Intermediate Clinical Research Fellowship |
| Start Date | 30 September 2013 |
| Duration | 4 years |
| Reference | FS/13/30/29994 |
| Status | Complete |
