Investigation of the differential role of calcineurin isoforms in persistent electrophysiological myocardial changes following regression from left ventricular hypertrophy
Dr Rita Jabr and Professor Christopher Fry from the University of Surrey will be investigating the potentially dangerous disturbances to heart rhythm that can occur as a result of cardiac hypertrophy. Cardiac hypertrophy is enlargement of the heart muscle, which is the body’s natural way to cope with increased demands placed on the heart for pumping blood. The researchers will look at how this enlargement affects the electrical activity in heart muscle. They are particularly interested in the activity of a protein called calcineurin, which is produced by heart cells during enlargement of the heart. It is thought that increased calcineurin activity may disrupt electrical conduction activity and therefore affect normal heart rhythm. Their results will help uncover some of the causes of dangerous heart rhythm changes.
Project details
| Grant amount | £137,748 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 11 July 2013 |
| Duration | 2 years |
| Reference | PG/12/64/29828 |
| Status | Complete |
