Studying what causes angina after exercise

Investigating the haemodynamic and physiological principles underlying exercise induced angina, and glyceryl trinitrate's anti-anginal effect, using invasive coronary and ventricular measures of coronary flow and cardiac work

Simon Redwood (lead researcher)

King's College London, St Thomas' Hospital

Start date: 06 October 2015 (Duration 3 years)

Supervised by Professor Simon Redwood, this Clinical Research Training Fellow is studying angina, chest pain that occurs when the blood supply to the heart muscle is restricted.

Coronary heart disease – when the arteries supplying the heart become hardened and narrowed – is usually the cause of angina. The pain is often triggered by physical activity or stress, typically lasts a few minutes, and symptoms improve after people use their glyceryl trinitrate spray. We don’t fully understand the mechanisms underlying exercise-induced angina, or how glyceryl trinitrate relieves the pain.

In this project, the researchers will study the relationship between two factors that cause angina after exercise - the heart’s blood supply and its workload. Patients will be asked to exercise until they develop angina, before they are given either glyceryl trinitrate therapy or a placebo. The fellow will study the effects of exercise and treatment on the blood supply to the heart and the work performed by the heart.

This research will give us greater insight into what causes exercise induced angina and how glyceryl trinitrate helps to relieve it. This knowledge could help design future therapies that mimic glyceryl trinitrate but treat angina more effectively.

Project details

Grant amount £230,305
Grant type Fellowship
Application type Clinical Research Training Fellowship
Start Date 06 October 2015
Duration 3 years
Reference FS/15/52/31587
Status In progress

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