The impact of cold on people with angina

Investigating the haemodynamic and physiological principles underlying cold induced angina using invasive coronary measures of flow and cardiac workload

Simon Redwood (lead researcher)

King's College London, St Thomas' Hospital

Start date: 21 January 2014 (Duration 3 years)

People with coronary heart disease can be affected by angina. Angina is a dull, heavy or tight chest pain caused by restricted blood flow to the heart – and importantly it could be a sign of being at risk of a future heart attack. Past research has hinted that the cold winter months can make the symptoms of angina much worse, but we don’t know why. For example, when it is cold some patients are able to do much less activity before they notice their angina coming on. A research team led by Professor Simon Redwood at King’s College London is investigating the underlying mechanisms causing angina and why death from coronary heart disease is higher in the winter months. The team will do a study in which patients with angina are exposed to cold air to simulate cold weather. They will monitor the effects of this exposure on the patients’ heart and circulatory system by measuring blood flow to the heart, blood pressure and heart rate using sophisticated measurement techniques. It is thought to be the first time that a study has looked at the effects of cold on this patient group. By better understanding the effects of exposure to the cold on the body, the researchers hope to improve treatment and monitoring of patients to reduce the impact of cold weather on heart patients.

Project details

Grant amount £217,536
Grant type Fellowship
Application type Clinical Research Training Fellowship
Start Date 21 January 2014
Duration 3 years
Reference FS/14/11/30526
Status Complete

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