Investigating the arrhythmogenic role of intracellular calcium and sarcoplasmic reticulum calcium content in a model of Torsade de Pointes
Some heart patients suffer from a condition called torsade de pointes – a dangerous change in heart rhythm. New treatments are urgently needed to combat this potentially life-threatening condition. Researchers have identified that the level of calcium in heart cells plays an important part in regulating heart rhythm, and that changes in calcium levels may trigger an abnormal heart rhythm. This University of Manchester team will investigate how calcium levels are controlled in heart cells. In particular they will look at the special ‘holes’ or channels in the surface of heart cells, through which calcium flows in and out. Understanding how these channels become damaged may lead to vital new ways to treat abnormal heart rhythm such as torsade de pointes.
Project details
| Grant amount | £244,716 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 March 2011 |
| Duration | 3 years |
| Reference | PG/10/89/28630 |
| Status | Complete |
