Global imaging and spatiotemporal analysis of angiogenesis and cell signalling events in live adult zebrafish (Ms Laura Wisniewski)
Supervised by Dr Paul Frankel, this PhD student is studying the processes that are important in angiogenesis, when new blood vessels form from existing vessels. Angiogenesis has a role in both the development of an organism and in various diseases. Although we know a lot about the molecules responsible for angiogenesis, we don’t yet fully understand how it is controlled. p130Cas is a member of a family of ‘adaptor’ proteins that interact with many other proteins. This protein family is important in controlling angiogenesis in both health and disease. p130Cas works by transmitting signals coming from outside the cell to other proteins inside the cell that are involved in regulating angiogenesis. In this project, the PhD student will study angiogenesis controlled by p130Cas in adult zebrafish. This research will help us understand what effect these proteins have on angiogenesis in the whole body of an organism, rather than just in single cells. The researchers will work out the key molecules needed for new blood vessel growth using a new imaging tool that will enable them to look inside live, adult zebrafish in a non-invasive way. This research will develop new imaging methods for scientists to study blood vessel growth in cells and zebrafish and will reveal more about the cell signalling required for vessel growth.
Project details
| Grant amount | £125,205 |
|---|---|
| Grant type | Fellowships |
| Application type | PhD Studentship |
| Start Date | 12 September 2016 |
| Duration | 3 years |
| Reference | FS/16/41/32235 |
| Status | In Progress |
