Why do people with coronary heart disease develop subsequent heart problems?

Genetic and phenotypic risk factors for subsequent coronary heart disease events

Riyaz Patel (lead researcher)

University College London

Start date: 01 February 2015 (Duration 4 years + 2 years)

Millions of people in the UK are living with coronary heart disease. Many of these people will unfortunately go on to have more heart problems, such as heart attack, heart failure and heart rhythm disturbance (arrhythmia). While we know much about the risk factors that cause coronary heart disease in otherwise healthy people (such as having high cholesterol), we know far less about why people who already have coronary heart disease develop further problems.

Cardiologist Dr Riyaz Patel from University College London has been awarded an Intermediate Clinical Research Fellowship to work under the guidance of BHF Professor John Deanfield. During his fellowship, Dr Patel will test to what extent the risk factors that cause coronary heart disease in otherwise healthy people are also associated with subsequent events in people who already have coronary heart disease. He will use computer-based health records to study nearly ten million people with heart disease. He will test whether their genes affect their risk of further heart problems by combining information from a global collaboration of over 50 studies of patients with heart disease with genetic information available in the UK Biobank. The UK Biobank is a ‘bank’ of biological samples from 500,000 people aged between 40-69 years from across the country, including blood, urine and saliva samples for future analysis and detailed information about the people supplying the samples, who have all agreed to have their health followed.

Using this information, he will be able to compare data from healthy people and people with heart disease to determine if they share the same genetic and non-genetic rick factors. He will also have biological samples to analyse alongside this data. All this information can be shared with other scientists who will use various technologies to study heart and circulatory disease and search for new targets for drugs.

By identifying and understanding the factors that cause further problems in people with heart disease, we can refine the way we treat this particular patient group and, hopefully, develop new drugs that could help them live long, healthy lives.

Project details

Grant amount £504,977
Grant type Fellowship
Application type Intermediate Clinical Research Fellowship
Start Date 01 February 2015
Duration 4 years + 2 years
Reference FS/14/76/30933
Status In progress

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