Evaluation of a novel physiological biomarker of hibernation in ischaemic left ventricular dysfunction (Dr Matthew Ryan)
Heart failure caused by narrowing of arteries in the heart is a common form of heart failure in the UK. This either leads to irreversible scarring of the heart muscle or causes the heart muscle to enter a state called myocardial hibernation, where the heart tissue remains alive but inactive. If the heart muscle is hibernating, it is possible to treat the narrowed arteries and restore heart function. But this is not the case if the heart tissue is scarred and permanently damaged. Accurately distinguishing between these two states is therefore crucial. Professor Divaka Perera is evaluating a new test to see whether it can distinguish between myocardial hibernation and scarring more effectively than the best test currently in use, cardiac magnetic resonance imaging (MRI). The new test simultaneously assesses the condition of the heart muscle and the small vessels supplying the muscle with blood. It will be studied in patients with heart failure scheduled for stent or coronary bypass surgery. If the new test can accurately predict myocardial hibernation, it could allow doctors to tailor stenting and bypass procedures to those individuals most likely to benefit. It would also prevent others from having procedures that are unlikely to be effective, reducing treatment complications.
Project details
| Grant amount | £265,699 |
|---|---|
| Grant type | Fellowships |
| Application type | Clinical Research Training Fellowship |
| Start Date | 01 March 2018 |
| Duration | 3 years, 1 month |
| Reference | FS/18/16/33396 |
| Status | In Progress |
