ERA-CVD transnational research projects on cardiovascular diseases:"Non-coding RNAs in cardiac macrophages and their role in heart failure" (parallel funding)
BHF Professor Manuel Mayr and his team at King’s College London are leaders in the high-tech field of cardiovascular proteomics. This is the study of all the proteins – called the proteome – in cells of the heart and blood stream. This grant will enable the team to collaborate and provide expertise to others across Europe in an international research programme. The aim is to understand the role of small molecules called micro RNAs – or miRNAs – in the progression of heart failure. Heart failure occurs when the heart does not have enough strength to pump blood around the body. The research teams believe that miRNAs might play a key role in inflammation of the heart, which occurs during heart failure. However, the specific roles of miRNAs are not yet well understood. Professor Mayr will be collaborating with researchers in Germany, the Netherlands and Belgium. His expertise in proteomics will enable them to identify which proteins are affected by different miRNAs in inflammatory cells in the heart. They will conduct their studies in cells and tissue samples from people with heart failure. It is hoped that finding out the role of miRNA molecules in this debilitating condition may open up avenues for new treatments.
Project details
| Grant amount | £271,596 |
|---|---|
| Grant type | Chairs & Programme Grants |
| Application type | Special Project |
| Start Date | 04 September 2017 |
| Duration | 3 years |
| Reference | SP/17/10/33219 |
| Status | In Progress |
