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How heart failure affects heart muscle cells

Professor Andrew Trafford (lead researcher)

University of Manchester

Start date: 01 November 2012 (Duration 5 years)

Dysfunctional β-Adrenergic Signalling in Heart Failure:  Impact on Cellular Calcium Homeostasis and Role as a Therapeutic Target

When you exercise or are frightened your heart pumps much harder due to the release of certain chemicals in the body. In heart diseases such as heart failure the muscle cells in the heart which are responsible for the pumping of blood fail to work harder when exposed to these chemicals. This research will study the reasons why the muscle cells of the heart do not respond properly to these chemicals, and how certain treatments used in heart failure affect heart cells.

Project details

Grant amount £1,186,190
Grant type Fellowships
Application type Senior Basic Science Research Fellowship
Start Date 01 November 2012
Duration 5 years
Reference FS/12/57/29717
Status Complete
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