Does shear stress sculpt focal atherosclerosis by inducing the NF-kB regulator Cezanne?
Heart attacks and strokes result from the build-up of fatty plaques within blood vessels, a condition called atherosclerosis. Branches and bends of arteries that are exposed to disturbed blood flow patterns are susceptible to inflammation and disease, whereas straighter regions exposed to undisturbed flow are protected. This PhD studentship at the University of Sheffield will study the mechanism for protection from disease at regions of undisturbed flow. Specifically, it will focus on the potential role of a gene called Cezanne which was discovered in 2001. Cezanne is known to protect cells grown in the laboratory from damage, and the current project will examine whether it protects arteries from disease.
Project details
| Grant amount | £112,830 |
|---|---|
| Grant type | Fellowships |
| Application type | PhD Studentship |
| Start Date | 01 August 2013 |
| Duration | 3 years |
| Reference | FS/13/27/30191 |
| Status | Complete |
