Does cellular insulin signalling modulate endogenous vascular repair and endothelial progenitor cell function via interaction with VEGF signalling?
People with diabetes are at increased risk of heart attacks and strokes because of damaged blood vessels. This is in part because diabetes interferes with the body's repair of blood vessels, which may be because of the reduced action of a powerful blood vessel growth factor Vascular Endothelial Growth Factor (VEGF). In this Intermediate Clinical Fellowship, Dr Cubbon will assess how processes that stimulate blood vessel healing and regeneration are altered by early diabetes. He will study blood vessel healing and new blood vessel growth using a series of experiments in models of early diabetes. The aim is to identify new ways of stimulating repair and regeneration of blood vessels in people with diabetes, possibly with drugs or stem cells.
Project details
| Grant amount | £1,179,189 |
|---|---|
| Grant type | Fellowships |
| Application type | Intermediate Clinical Research Fellowship |
| Start Date | 01 February 2013 |
| Duration | 7 years |
| Reference | FS/12/80/29821 |
| Status | In Progress |
