Why do some patients with heart failure have a normal ejection fraction?

Diastolic ventricular interaction in patients with heart failure with normal ejection fraction

Michael Frenneaux (lead researcher)

East Anglia, University of

Start date: 01 August 2013 (Duration 2 years 6 months)

People with heart failure experience symptoms such as breathlessness, fatigue and swelling that develop when the heart struggles to pump blood efficiently around the body. But some people with symptoms of heart failure appear to have hearts that can pump normally according to current tests.

Professor Michael Frenneaux and colleagues have been awarded a two-year grant to understand why some people whose hearts appear to pump normally, show symptoms of heart failure including breathlessness during exercise. The problem seems to be that the heart becomes stiff during exercise, preventing it filling properly. Professor Michael Frenneaux wants to find out whether this is down to a vicious cycle of high pressure in the heart that stops it from pumping properly. 60 people with this type of heart failure will be recruited to the study and undergo an array of intricate tests to help doctors understand exactly what happens to their heart and blood flow during exercise. The research could lead to new therapies, such as a special kind of pacemaker, to help return the heart’s function to normal.

Project details

Grant amount £166,083
Grant type Project Grant
Start Date 01 August 2013
Duration 2 years 6 months
Reference PG/13/4/29811
Status In progress

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