Can ripple mapping guided ablation therapy reduce ventricular rhythm disturbances?

Determining the pathophysiological role of slow conduction channels identified by ripple mapping of the ventricular scar

Prapa Kanagaratnam (lead researcher)

Imperial College London, St Mary's Hospital

Start date: 01 February 2015 (Duration 3 years)

Following a heart attack, part of the heart muscle dies and is replaced by scar tissue. But within the scar, there often remain channels of living tissue that can form a short circuit around the scar, leading to electrical disturbances (arrhythmias) that are potentially life threatening. The commonest of these is ventricular tachycardia (VT), which causes around 300,000 deaths per year. One way to treat VT is called VT ablation, which involves identifying these channels and burning (ablating) them – but this procedure is not very effective. Patients at risk of dying receive an Implantable Cardioverter Defibrillator (ICD) which delivers an internal shock when the patient suffers VT. But these patients are subject to recurrent and painful shocks, significantly reducing their quality of life, and the ICD doesn’t treat the underlying cause. We need to find new ways to treat these electrical disturbances. The Imperial team have created a novel way of finding the problem channels so they can treat VT, called Ripple Mapping (RM). In this Clinical Research Training Fellowship, they will carry out a clinical study to find out if Ripple Maple can better prevent VT recurrence. Patients with VT will receive either Ripple Mapping guided VT ablation, or conventional ablation treatments – and the fellow will compare how often patients receive defibrillator treatments over two years. This research may reveal a new way to prevent VT recurrence and help patients to avoid painful shock treatments, and may significantly improve the quality of life of patients with these arrhythmias.

Project details

Grant amount £153,492
Grant type Fellowship
Application type Clinical Research Training Fellowship
Start Date 01 February 2015
Duration 3 years
Reference FS/15/12/31239
Status Complete

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