Control of VWF function by structural elements within its A2 domain, the vicinal disulphide bond and calcium binding site
Following blood vessel injury, platelets are needed to form a blood clot and mend the vessel. Von Willebrand factor (VWF) a ‘sticky’ protein, helps platelets bind to the site of injury. VWF must unfold at the molecular level for this to happen. Professor David Lane at Imperial college London have been awarded a PhD studentship to allow a young researcher to study the properties of the unfolding process and how platelets influence this process. Understanding how VWF and platelets work together is important for our understanding of the blood clotting process, and what goes wrong when a blood clot forms inside a vessel (thrombosis), which can lead to a heart attack or stroke.
Project details
| Grant amount | £130,170 |
|---|---|
| Grant type | Fellowships |
| Application type | PhD Studentship |
| Start Date | 01 June 2014 |
| Duration | 3 years |
| Reference | FS/14/21/30733 |
| Status | Complete |
