Control of endothelial quiescence as a regulator of angiogenesis
Angiogenesis – the process of growing new blood vessels – is important throughout our lives. But it can also contribute to many diseases when it goes wrong, by being too active (cancer) or not active enough (vessel disease). The ability to modify blood vessel growth would help in the quest to develop new treatments for diseases such as heart failure, diabetes and cancer. Dr Andrew Benest and his team are studying a protein called Zeb1 that is important to ensure that the cells lining the inner surface of the blood vessel, the endothelial cells, form a stable structure. In this project, they will test whether removing Zeb1 can ‘activate’ the endothelial cells and increase the formation of new blood vessels in a model of peripheral vascular disease, a blood circulation disorder. This research could help to identify new drugs targeting Zeb1 to potentially stop or increase the formation of new blood vessels.
Project details
| Grant amount | £137,852 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 February 2019 |
| Duration | 2 years |
| Reference | PG/18/31/33759 |
| Status | In Progress |
