Can phospholipids in platelets explain bleeding or clotting diseases?

Characterisation of platelet and microparticle phospholipids in thrombotic and bleeding disorders

Peter Collins (lead researcher)

Cardiff University

Start date: 03 October 2016 (Duration 3 years)

Supervised by Professor Peter Collins, the Clinical Research Training Fellow on this grant is studying how fatty ‘phospholipid’ molecules affect blood clotting.

The blood clotting process, called coagulation, takes place on the surface of small cells in the blood called platelets. Phospholipids in the platelet membrane and in tiny packages (microparticles) that are released from activated platelets help to control how clots form. The team now wants to find out whether changes in the types of phospholipid on the surface of platelets or microparticles could explain why some people are more prone to blood clotting or bleeding disorders.

In this project, the fellow will study platelets from healthy people and from people with unexplained bleeding disorders or clotting disorders, for example, people who’ve had a heart attack or a clot in their veins (deep venous thrombosis, DVT). The team will identify the type of phospholipid found on the surface of platelets and microparticles in these people, and will study whether clots develop differently on platelets from people with bleeding or clotting disorders compared with healthy platelets.

Understanding the role of phospholipids in bleeding and clotting diseases may reveal why some people are more prone to these conditions than others. It could also lead to a more ‘personalised’ way of treating bleeding and clotting disorders.

Project details

Grant amount £234,333
Grant type Fellowship
Application type Clinical Research Training Fellowship
Start Date 03 October 2016
Duration 3 years
Reference FS/16/20/32005
Status In progress

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