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Can MRI be used as a reliable tool to assess heart microstructure?

Professor Jurgen E Schneider (lead researcher)

University of Oxford

Start date: 03 February 2014 (Duration 3 years)

Assessment of non-Gaussian diffusion to improve the accuracy of structural MR imaging and computational modelling of normal and diseased hearts

Understanding the in-depth structure of the heart is crucial to help researchers know how the heart works and develop new computer models of the heart. The way heart cells are orientated and arranged in layers within the heart muscle (the heart microstructure) defines how the heart works. Magnetic resonance imaging, or MRI, is a medical imaging technology, which allows doctors and researchers to look at the heart and circulatory system in minute detail. This means you can diagnose conditions without invasive surgery. Dr Jurgen Schneider and colleagues, who are experts in heart MRI and computer modelling, have been awarded a grant to find out if MRI can be used as a reliable tool in the clinic to assess heart microstructure. They will develop techniques and validate them in both normal and damaged mouse hearts. This knowledge may reveal new insights into heart and circulatory disease, and help develop novel diagnostic methods to test treatments and predict disease progression in the future.

Project details

Grant amount £279,175
Grant type Project Grants
Application type Project Grant
Start Date 03 February 2014
Duration 3 years
Reference PG/13/33/30210
Status Complete
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