An In silico model of action potential propagation, biologically validated in the HL1-6 myocyte cell line: A framework for characterising myocardial re-entry and fibrillation in the human heart
Dr Emmanuel Dupont and his team at Imperial College London are testing a new computer simulation, which would allow researchers to study abnormal heart rhythms. To beat regularly, the heart contracts in response to complex electrical circuits. In heart disease, such as after a heart attack or with ageing, these circuits are disturbed and this leads to abnormal heart rhythms (arrhythmias) that can be fatal. The electrical circuits in the heart are difficult to study directly, so computer models are becoming an invaluable tool to help scientists understand how they work. However, these computer simulations need to be verified by biological experiments first to ensure they accurately reflect what happens in the heart. In this project the researchers will develop and verify a computer model that mimics the abnormal electrical function in the diseased heart. The model will be designed to mimic a simple type of abnormal electrical circuit found in cells that can be grown in the laboratory. The researchers will then adapt this simulation to mimic the abnormal circuits found in the diseased heart. This computer model will be a valuable tool to help researchers better understand abnormal rhythms in people with heart disease and may help to develop new treatments.
Project details
| Grant amount | £325,160 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 December 2015 |
| Duration | 3 years |
| Reference | PG/15/59/31621 |
| Status | Complete |
