A project assessing the in-vivo properties of a prolyl hydroxylase inhibitor FG-2216-eluting stent on angiogenesis in an animal model
Total blockage of a coronary artery, or chronic total occlusion (CTO), causes painful angina. Around 30 per cent of people with CTO cannot be adequately treated by current therapy. Professor Anthony Gershlick from the University of Leicester has been awarded a grant to develop a new treatment for this condition, using a metal stent - a spring-like structure that keeps the artery open. When placed close to the blockage, the new stent releases a drug to encourage the growth of new tiny blood vessels to restore blood flow around the obstruction. In this project, the researchers will test a drug called FG-2216 which has already been used to treat patients with kidney disease. They will develop FG-2216-loaded stents, and test them in a rabbit model of blocked arteries, to find out if they work. Restoring blood flow to the heart with this new method will reduce the risk of damage to the heart muscle, and aims to improve symptoms of angina and increase survival.
Project details
| Grant amount | £170,028 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 February 2015 |
| Duration | 1 year, 6 months |
| Reference | PG/14/94/31243 |
| Status | Complete |
