A novel mechanism of coronary hypoxic vasodilatation involving hydrogen sulphide
Every year thousands of people suffer a heart attack, which starves the heart of oxygen. To help preserve its function, the heart and circulatory system respond by undergoing various changes that attempt to reduce the damage. One of these is that the coronary artery - the main artery which supplies the heart with oxygenated blood - widens to try to increase supply. However, the mechanisms behind the response are not fully understood. Dr Vera Ralevic’s team from the University of Nottingham is building on their earlier findings that under these conditions the heart produces a gas called hydrogen sulphide, which widens the coronary artery. They will characterise this response further in the hope that it may lead to new treatments for heart-attack patients and other heart conditions that occur because of oxygenation shortages in the heart such as angina or heart failure.
Project details
| Grant amount | £164,797 |
|---|---|
| Grant type | Project Grants |
| Application type | Project Grant |
| Start Date | 01 March 2012 |
| Duration | 3 years |
| Reference | PG/11/45/28975 |
| Status | Complete |
