May 2015 - New Grants

Gel electrophoresis to separate proteins Can intravenous iron improve outcomes in people with heart failure? Is iron therapy cost effective? The IRONMAN trial, led by Dr Paul Kalra and Professor Ian Ford will recruit over 1000 patients with heart failure from across the UK to answer these important questions. 


Read on to find out about the new grants we've funded since the last newsletter.

Project Grants

PG/15/1/31217
Dr Mark Pearce et al.
University of Newcastle upon Tyne
Radiation doses and associated risks from cardiac catheterizations in children and young adults
2 years
£89,819

PG/15/2/31208
Professor Michelle Peckham et al.
University of Leeds
Understanding how mutations in subfragment-2 of β-cardiac myosin heavy chain contribute to hypertrophic cardiomyopathy
3 years
£208,184 

PG/15/3/31226
Dr Lingfang Zeng et al.
King's College London
The role of histone deacetylase 7-derived peptides in mobilization and differentiation of vascular progenitor cells
3 years
£243,976

PG/15/4/31178
Professor Ioakim Spyridopoulos et al.
University of Newcastle upon Tyne
Targeting the sphingosine-1 phosphate pathway to reduce myocardial ischemia / reperfusion injury
2 years
£113,430

PG/15/5/31110
Professor Manuela Zaccolo
University of Oxford
Phosphodiesterase 3 isoforms and beta-adrenergic control of cardiac myocyte function
3 years
£257,501

PG/15/6/31211
Professor Peter Scambler
University College London
Regulation of transcription and variant histone deposition by HIRA during heart development
3 years
£230,624

PG/15/7/31235
Professor Darrel Francis et al.
Imperial College London
Statin side effect or not? A patient-empowering within-subject randomized controlled trial and development of a practical technology to support 21st century primary prevention decisions
3 years
£289,669

PG/15/8/31130
Dr Oleg Aslanidi et al.
King's College London
Dissecting multifactorial mechanisms of atrial fibrillation: predictive modelling framework for evaluating medical treatments
3 years
£190,956

PG/15/9/31270
Dr Alan Stewart et al.
University of St Andrews
Role of zinc in controlling histidine-rich glycoprotein complex formation: implications for the development of thrombotic complications
3 years
£188,250

PG/15/10/31277
Dr Patrick Hadoke et al.
University of Edinburgh
11ß-hydroxysteroid dehydrogenase type 1 inhibition as a novel treatment for peripheral arterial disease
3 years
£295,990

PG/15/11/31279
Dr Qingzhong Xiao
Queen Mary, University of London
Functional roles of hnRNPA1 in vascular smooth muscle cell phenotype modulation and neointima hyperplasia
3 years
£237,031

PG/15/12/31280
Dr Folma Buss et al.
Cambridge, University of" Myosin VI as a novel regulator of cardiac autophagy - a potential target for the treatment of heart failure triggered by autophagic cell death
3 years
£221,176

PG/15/13/31296
Dr Isabel Orriss et al.
Royal Veterinary College, University of London
Extracellular nucleotides and the P2Y2 receptor: potential targets for the inhibition of vascular calcification
2 years
£167,433

PG/15/14/31311
Dr Anne-Marie O'Carroll et al.
University of Bristol
Unravelling the role of the apelin-apelin receptor system in essential hypertension
3 years
£225,955

PG/15/15/31316
Dr Stephen Yarwood et al.
University of Glasgow
Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1
3 years
£220,852

PG/15/16/31330
Professor Mark R Boyett et al.
University of Manchester
Why do bradyarrhythmias occur at night? An intrinsic circadian clock in the cardiac conduction system?
3 years
£214,177

PG/15/17/31332
Dr Timothy Chico et al.
University of Sheffield 
The effect of mutations of the ciliary proteins ift88 and ift54 on angiogenesis and mechanotransduction in zebrafish
3 years
£244,152

PG/15/18/31333
Dr David Grieve et al.
Queen's University, Belfast
Endothelial Nox2 NADPH oxidase as a key driver of adverse cardiac remodelling associated with diabetes
3 years
£288,416

PG/15/19/31336
Dr Claire  Nightingale et al.
St George's, University of London
Body fatness, overweight and obesity in UK south asian and black african children and adolescents:  accurately assessing current patterns and recent time trends and providing improved body mass index (BMI) thresholds for diagnosis of overweight and obesity
2 years
£107,786

PG/15/20/31339
Dr Fu Siong Ng et al.
Imperial College London
Predicting sudden arrhythmic death: electrophysiological phenotyping to define the clinical signatures of risk in the inherited cardiac conditions
2 years 6 months
£240,512

PG/15/21/31355
Professor Jonathan Gibbins et al.
University of Reading, 
Protein sumoylation in platelets: a potential new signalling paradigm in the control of haemostasis and thrombosis
3 years
£213,436

PG/15/22/31360
Dr Mark C Pfuhl et al.
King's College London
Unravelling the mystery of the hierarchical phosphorylation of MyBP-C and its importance for differential interactions with actin and myosin
3 years
£287,168

PG/15/23/31362
Dr Richard Weller et al.
University of Edinburgh, 
A trial of daily ultraviolet therapy to reduce cardiovascular risk factors
3 years
£252,384

PG/15/24/31367
Professor Angela Clerk
University of Reading 
p90 ribosomal S6 kinase 1 (RSK1) and the regulation of gene expression in pathological and physiological cardiac hypertrophy
3 years
£278,941

PG/15/25/31369
Dr Stephen Robinson
University of East Anglia
Deciphering the angiogenic tug-of war between neuropilin-1 interacting integrins
1 year
£87,417

PG/15/26/31373
Professor Philip Eaton
King's College London
Expanding our understanding of the redox regulation of soluble Epoxide Hydrolase in cardiovascular health and disease
3 years
£250,143

PG/15/27/31374
Dr Alison C Brewer et al.
King's College London" Promoting cardiac proliferation within the adult mammalian heart by pharmacological inhibition of DUSP6- and GSK3ß-dependent signalling
3 years
£232,059

PG/15/28/31384
Professor Aleksandar J Jovanovic
University of Dundee 
IES SUR2B-mediated cardioprotection
3 years
£170,346

PG/15/29/31388
Professor Nicholas Hastie et al.
University of Edinburgh 
Dissecting the functional role of novel Wt1 regulated pathways during epicardium development and heart repair
3 years
£297,551

PG/15/30/31390
Dr Jason L Johnson et al.
University of Bristol 
MMP-12 inhibition as a therapy for abdominal aortic aneurysm formation and progression
2 years
£148,358

PG/15/31/31393
Professor Angela Clerk
University of Reading 
Receptor-interacting serine-threonine kinases, RIPK1 and RIPK3, in cardiac myocyte apoptosis and necroptosis
3 years
£202,615

PG/15/32/31398
Professor Paolo Madeddu et al.
University of Bristol
Neonatal cardiac pericytes engineered grafts for correction of congenital heart defects
3 years
£179,569

PG/15/33/31394
Professor Massimo Caputo et al.
University of Bristol
The cardio-protective efficacy of cardioplegic solution supplemented with Sildenafil in neonatal pig model of cardiopulmonary bypass and cardioplegic arrest
2 years
£193,500

Fellowships

Non-Clinical Fellowships

Intermediate Basic Science Research Fellowships

FS/15/15/31364
Dr Ricardo Carnicer Hijazo 
University of Oxford
An unexpected role of tetrahydrobiopterin (BH4) in diabetic cardiomyopathy  
4 years
£481,114

FS/15/16/31477
Dr Wei Liu 
University of Manchester
Investigating a novel mechanism of cardiac glucose metabolism regulation in diabetes
4 years
£300,300

Career Re-entry Research Fellowships

FS/15/17/31411
Dr Marco Massimiliano Meloni 
St George's, University of London
Magnetic resonance imaging of atherosclerosis - A novel pretargeted approach
3 years
£243,038 

PhD Studentships 

FS/15/18/31317
Dr Neil Morgan 
University of Birmingham
Identification and functional investigation of genes in patients with inherited bleeding disorders
3 years
£141,561 

FS/15/19/31327
Professor Simi Ali (Miss Sarah Thompson)
University of Newcastle 
Post-translation modification of chemokines during heart transplantation: Implications for their biological function
3 years
£105,343 

FS/15/20/31335
Professor Richard Farndale (Ms Emma Hunter)
University of Cambridge
The roles of the collagen binding integrins in the regulation of endothelial cell function and behaviour
3 years
£117,918 

FS/15/21/31424
Dr Liguo Zhao 
Loughborough University
Towards controlling the mechanical performance of polymeric bioresorbable vascular scaffold during biodegradation 
3 years
£104,347

FS/15/22/31356
Dr Stavroula Balabani 
University College London
Investigation of the haemodynamics of dissected aortas: an in vitro, in-vivo and in-silico study
3 years
£96,721

FS/15/23/31435
Dr Andriana Margariti (Miss Rachel Caines)
Queen's University Belfast
Dedifferentiated or re-Born Again? Elucidating the chromatin remodelling mechanisms during endothelial cell reprogramming for cardiovascular therapy
3 years
£107,172

FS/15/24/31459
Dr Georgia Mavria (Ms Lenka Stejkal)
University of Leeds
Characterising the in vitro and in vivo roles of the small GTPase RhoG in regulating angiogenesis
3 years
£107,164

Clinical Fellowships

Intermediate Clinical Research Fellowships  

FS/15/25/31423
Dr Nick Linton 
Imperial College London
Development of patient-specific tools to determine the need for adjunctive ablation following PVI for persistent AF using detailed characterisation of the substrate and the mode of recurrence
4 years
£361,712

Clinical Research Training Fellowships

FS/15/26/31441
Professor Martin Bennett (Dr Charis Costopoulos)
University of Cambridge
Finite element analysis and imaging to predict human atherosclerotic plaque growth and progression to instability
2 years
£116,678

FS/15/27/31465
Professor Sanjay Sharma (Dr Andrew D'Silva)
St George's, University of London 
Increased left ventricular trabeculation in athletes – a marker of left ventricular non-compaction or a physiological epiphenomenon of increased cardiac preload?
3 years
£163,380

FS/15/28/31476
Professor Andrew Trafford (Dr David Hutchings)
University of Manchester
Understanding the mechanisms by which phosphodiesterase 5 inhibition is protective against arrhythmias in heart failure
3 years
£217,179

FS/15/29/31492
Dr Sanjay Prasad (Dr Brian Halliday)
Imperial College London
Is it safe to withdraw medical therapy from patients with a previous diagnosis of dilated cardiomyopathy, now in remission?
3 years
£186,676

Infrastructure Grants

IG/15/1/31328                                  
Dr Timothy Chico et al.
University of Sheffield, 
Funding towards a Zeiss Z.1 single plane illumination microscope (SPIM) 1 year
£243,180

Special Projects 

SP/15/1/31471                                  
Professor Chris Denning et al.
University of Nottingham
Gene targeted optogenetics in hPSC-cardiovascular cells for transplantation into animal models of heart dysfunction (Joint funding with BIRAX)
3 years
£200,000

SP/15/2/31472                                  
Professor Paul Riley et al.
University of Oxford 
Investigating the niche-like microenvironment of the epicardium and its role in signalling to facilitate heart regeneration (Joint funding with BIRAX)
3 years
£200,000

SP/15/3/31473                                  
Professor Bruno Peault et al.
University of Edinburgh
Pericytes from human pluripotent stem cells for cardiac regeneration (Joint funding with BIRAX)
3 years
£200,000

SP/15/4/31535                                  
Professor Sir Nilesh J Samani
University of Leicester 
Telomere length measurement in UK Biobank: advancing understanding of biological ageing and age related diseases (Joint funding with MRC & BBSRC)
4 years
£619,867

Programme Grants

RG/15/1/31165                                  
Professor Michael Schneider et al.
Imperial College London
Dormant stem cells from adult myocardium (renewal)
4 years
£1,000,000

RG/15/2/31224                                  
Professor Jonathan Gibbins et al.
University of Reading
The physiological importance and integration of receptor-mediated inhibitory mechanisms in platelets in health and disease (renewal)
5 years
£1,426,158

RG/15/3/31236                                  
Professor Ken Suzuki et al.
Queen Mary, University of London
Epicardial placement of stem cells for Mending Broken Hearts
5 years
£782,021

RG/15/4/31268                                  
Professor Richard W Farndale
University of Cambridge
Collagen-like peptides: synthetic tools to investigate vascular cell function in health and disease (renewal)
3 years, 6 months
£721,676

Clinical Study Grants

CS/15/1/31175                                  
Dr Paul R Kalra et al.
Effectiveness of Intravenous iron treatment vs standard care in patients with heart failure and iron deficiency: a randomised, open-label multicentre trial (IRON-MAN)
5 years
£1,724,196

CS/15/2/31331                                  
Professor Simon G Ray et al.
University of Manchester 
UK Early Mitral Surgery trial
5 years
£1,543,819