May 2015 - New Grants

Gel electrophoresis to separate proteins Can intravenous iron improve outcomes in people with heart failure? Is iron therapy cost effective? The IRONMAN trial, led by Dr Paul Kalra and Professor Ian Ford will recruit over 1000 patients with heart failure from across the UK to answer these important questions. 

Read on to find out about the new grants we've funded since the last newsletter.

Project Grants

Dr Mark Pearce et al.
University of Newcastle upon Tyne
Radiation doses and associated risks from cardiac catheterizations in children and young adults
2 years

Professor Michelle Peckham et al.
University of Leeds
Understanding how mutations in subfragment-2 of β-cardiac myosin heavy chain contribute to hypertrophic cardiomyopathy
3 years

Dr Lingfang Zeng et al.
King's College London
The role of histone deacetylase 7-derived peptides in mobilization and differentiation of vascular progenitor cells
3 years

Professor Ioakim Spyridopoulos et al.
University of Newcastle upon Tyne
Targeting the sphingosine-1 phosphate pathway to reduce myocardial ischemia / reperfusion injury
2 years

Professor Manuela Zaccolo
University of Oxford
Phosphodiesterase 3 isoforms and beta-adrenergic control of cardiac myocyte function
3 years

Professor Peter Scambler
University College London
Regulation of transcription and variant histone deposition by HIRA during heart development
3 years

Professor Darrel Francis et al.
Imperial College London
Statin side effect or not? A patient-empowering within-subject randomized controlled trial and development of a practical technology to support 21st century primary prevention decisions
3 years

Dr Oleg Aslanidi et al.
King's College London
Dissecting multifactorial mechanisms of atrial fibrillation: predictive modelling framework for evaluating medical treatments
3 years

Dr Alan Stewart et al.
University of St Andrews
Role of zinc in controlling histidine-rich glycoprotein complex formation: implications for the development of thrombotic complications
3 years

Dr Patrick Hadoke et al.
University of Edinburgh
11ß-hydroxysteroid dehydrogenase type 1 inhibition as a novel treatment for peripheral arterial disease
3 years

Dr Qingzhong Xiao
Queen Mary, University of London
Functional roles of hnRNPA1 in vascular smooth muscle cell phenotype modulation and neointima hyperplasia
3 years

Dr Folma Buss et al.
Cambridge, University of" Myosin VI as a novel regulator of cardiac autophagy - a potential target for the treatment of heart failure triggered by autophagic cell death
3 years

Dr Isabel Orriss et al.
Royal Veterinary College, University of London
Extracellular nucleotides and the P2Y2 receptor: potential targets for the inhibition of vascular calcification
2 years

Dr Anne-Marie O'Carroll et al.
University of Bristol
Unravelling the role of the apelin-apelin receptor system in essential hypertension
3 years

Dr Stephen Yarwood et al.
University of Glasgow
Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1
3 years

Professor Mark R Boyett et al.
University of Manchester
Why do bradyarrhythmias occur at night? An intrinsic circadian clock in the cardiac conduction system?
3 years

Dr Timothy Chico et al.
University of Sheffield 
The effect of mutations of the ciliary proteins ift88 and ift54 on angiogenesis and mechanotransduction in zebrafish
3 years

Dr David Grieve et al.
Queen's University, Belfast
Endothelial Nox2 NADPH oxidase as a key driver of adverse cardiac remodelling associated with diabetes
3 years

Dr Claire  Nightingale et al.
St George's, University of London
Body fatness, overweight and obesity in UK south asian and black african children and adolescents:  accurately assessing current patterns and recent time trends and providing improved body mass index (BMI) thresholds for diagnosis of overweight and obesity
2 years

Dr Fu Siong Ng et al.
Imperial College London
Predicting sudden arrhythmic death: electrophysiological phenotyping to define the clinical signatures of risk in the inherited cardiac conditions
2 years 6 months

Professor Jonathan Gibbins et al.
University of Reading, 
Protein sumoylation in platelets: a potential new signalling paradigm in the control of haemostasis and thrombosis
3 years

Dr Mark C Pfuhl et al.
King's College London
Unravelling the mystery of the hierarchical phosphorylation of MyBP-C and its importance for differential interactions with actin and myosin
3 years

Dr Richard Weller et al.
University of Edinburgh, 
A trial of daily ultraviolet therapy to reduce cardiovascular risk factors
3 years

Professor Angela Clerk
University of Reading 
p90 ribosomal S6 kinase 1 (RSK1) and the regulation of gene expression in pathological and physiological cardiac hypertrophy
3 years

Dr Stephen Robinson
University of East Anglia
Deciphering the angiogenic tug-of war between neuropilin-1 interacting integrins
1 year

Professor Philip Eaton
King's College London
Expanding our understanding of the redox regulation of soluble Epoxide Hydrolase in cardiovascular health and disease
3 years

Dr Alison C Brewer et al.
King's College London" Promoting cardiac proliferation within the adult mammalian heart by pharmacological inhibition of DUSP6- and GSK3ß-dependent signalling
3 years

Professor Aleksandar J Jovanovic
University of Dundee 
IES SUR2B-mediated cardioprotection
3 years

Professor Nicholas Hastie et al.
University of Edinburgh 
Dissecting the functional role of novel Wt1 regulated pathways during epicardium development and heart repair
3 years

Dr Jason L Johnson et al.
University of Bristol 
MMP-12 inhibition as a therapy for abdominal aortic aneurysm formation and progression
2 years

Professor Angela Clerk
University of Reading 
Receptor-interacting serine-threonine kinases, RIPK1 and RIPK3, in cardiac myocyte apoptosis and necroptosis
3 years

Professor Paolo Madeddu et al.
University of Bristol
Neonatal cardiac pericytes engineered grafts for correction of congenital heart defects
3 years

Professor Massimo Caputo et al.
University of Bristol
The cardio-protective efficacy of cardioplegic solution supplemented with Sildenafil in neonatal pig model of cardiopulmonary bypass and cardioplegic arrest
2 years


Non-Clinical Fellowships

Intermediate Basic Science Research Fellowships

Dr Ricardo Carnicer Hijazo 
University of Oxford
An unexpected role of tetrahydrobiopterin (BH4) in diabetic cardiomyopathy  
4 years

Dr Wei Liu 
University of Manchester
Investigating a novel mechanism of cardiac glucose metabolism regulation in diabetes
4 years

Career Re-entry Research Fellowships

Dr Marco Massimiliano Meloni 
St George's, University of London
Magnetic resonance imaging of atherosclerosis - A novel pretargeted approach
3 years

PhD Studentships 

Dr Neil Morgan 
University of Birmingham
Identification and functional investigation of genes in patients with inherited bleeding disorders
3 years

Professor Simi Ali (Miss Sarah Thompson)
University of Newcastle 
Post-translation modification of chemokines during heart transplantation: Implications for their biological function
3 years

Professor Richard Farndale (Ms Emma Hunter)
University of Cambridge
The roles of the collagen binding integrins in the regulation of endothelial cell function and behaviour
3 years

Dr Liguo Zhao 
Loughborough University
Towards controlling the mechanical performance of polymeric bioresorbable vascular scaffold during biodegradation 
3 years

Dr Stavroula Balabani 
University College London
Investigation of the haemodynamics of dissected aortas: an in vitro, in-vivo and in-silico study
3 years

Dr Andriana Margariti (Miss Rachel Caines)
Queen's University Belfast
Dedifferentiated or re-Born Again? Elucidating the chromatin remodelling mechanisms during endothelial cell reprogramming for cardiovascular therapy
3 years

Dr Georgia Mavria (Ms Lenka Stejkal)
University of Leeds
Characterising the in vitro and in vivo roles of the small GTPase RhoG in regulating angiogenesis
3 years

Clinical Fellowships

Intermediate Clinical Research Fellowships  

Dr Nick Linton 
Imperial College London
Development of patient-specific tools to determine the need for adjunctive ablation following PVI for persistent AF using detailed characterisation of the substrate and the mode of recurrence
4 years

Clinical Research Training Fellowships

Professor Martin Bennett (Dr Charis Costopoulos)
University of Cambridge
Finite element analysis and imaging to predict human atherosclerotic plaque growth and progression to instability
2 years

Professor Sanjay Sharma (Dr Andrew D'Silva)
St George's, University of London 
Increased left ventricular trabeculation in athletes – a marker of left ventricular non-compaction or a physiological epiphenomenon of increased cardiac preload?
3 years

Professor Andrew Trafford (Dr David Hutchings)
University of Manchester
Understanding the mechanisms by which phosphodiesterase 5 inhibition is protective against arrhythmias in heart failure
3 years

Dr Sanjay Prasad (Dr Brian Halliday)
Imperial College London
Is it safe to withdraw medical therapy from patients with a previous diagnosis of dilated cardiomyopathy, now in remission?
3 years

Infrastructure Grants

Dr Timothy Chico et al.
University of Sheffield, 
Funding towards a Zeiss Z.1 single plane illumination microscope (SPIM) 1 year

Special Projects 

Professor Chris Denning et al.
University of Nottingham
Gene targeted optogenetics in hPSC-cardiovascular cells for transplantation into animal models of heart dysfunction (Joint funding with BIRAX)
3 years

Professor Paul Riley et al.
University of Oxford 
Investigating the niche-like microenvironment of the epicardium and its role in signalling to facilitate heart regeneration (Joint funding with BIRAX)
3 years

Professor Bruno Peault et al.
University of Edinburgh
Pericytes from human pluripotent stem cells for cardiac regeneration (Joint funding with BIRAX)
3 years

Professor Sir Nilesh J Samani
University of Leicester 
Telomere length measurement in UK Biobank: advancing understanding of biological ageing and age related diseases (Joint funding with MRC & BBSRC)
4 years

Programme Grants

Professor Michael Schneider et al.
Imperial College London
Dormant stem cells from adult myocardium (renewal)
4 years

Professor Jonathan Gibbins et al.
University of Reading
The physiological importance and integration of receptor-mediated inhibitory mechanisms in platelets in health and disease (renewal)
5 years

Professor Ken Suzuki et al.
Queen Mary, University of London
Epicardial placement of stem cells for Mending Broken Hearts
5 years

Professor Richard W Farndale
University of Cambridge
Collagen-like peptides: synthetic tools to investigate vascular cell function in health and disease (renewal)
3 years, 6 months

Clinical Study Grants

Dr Paul R Kalra et al.
Effectiveness of Intravenous iron treatment vs standard care in patients with heart failure and iron deficiency: a randomised, open-label multicentre trial (IRON-MAN)
5 years

Professor Simon G Ray et al.
University of Manchester 
UK Early Mitral Surgery trial
5 years