December 2015 - New grants

Gel electrophoresis to separate proteins

With this update we welcome our new BHF Professor Federica Marelli-Berg who researches cardiovascular immunology at Queen Mary University of London.

Read on to find out about other grants that have been recently awarded.

BHF Chair of Cardiovascular Immunology

CH/15/2/32064

Professor Federica Marelli Berg

Queen Mary, University of London

10 years 

£1,072,526

Senior Basic Science Research Fellowship 

FS/15/56/31645 

Professor Leanne Hodson 

University of Oxford

Heterogeneity in hepatic synthesis pathways may influence the development of non-alcoholic fatty liver disease (NAFLD) and atherogenic dyslipidaemia: studies in humans using in vivo and in vitro approaches 

5 years 

£995,475

Intermediate Basic Science Research Fellowships

FS/15/57/31557 

Dr Andrew Sage 

University of Cambridge

Understanding the pathogenic role of B cells in atherosclerosis 

4 years 

£423,428


FS/15/58/31784 

Dr Alexandra Mazharian 

University of Birmingham

A novel mechanism controlling platelet production involving suppression of ERK1/2 by DUSP1/6 

4 years 

£484,415 


FS/15/59/31839 

Dr Christopher Rhodes 

Imperial College London

Molecular phenotyping of pulmonary hypertension 

4 years 

£395,949

Immediate PostDoctoral Basic Science Research Fellowships

FS/15/60/31510 

Dr Robert Menzies 

University of Edinburgh

Druggable target discovery in hypertensive renal injury: vascular purinergic receptor X7 

3 years 

£229,524 


FS/15/61/31626 

Dr Loes Rutten Jacobs 

University of Cambridge 

Identification of novel pathophysiological mechanisms in cerebral small vessel disease: an epidemiologic and genetic approach 

3 years 

£126,016

Programme Grants 

RG/15/14/31880                                  

Professor Peter Scambler

University College London 

Morphogenetic Signalling Pathways Affected in DiGeorge and Charge Syndromes: Their Role in Cardiovascular Development (renewal) 

5 years 

£1,415,379


RG/15/15/31742                                  

Professor Andrew Tinker

Queen Mary, University of London 

The role of the ATP-sensitive potassium channels in cardiovascular physiology and disease (renewal) 

5 years 

£1,091,688

RG/15/16/31758                                  

Professor Alastair Poole et al.

Bristol, University of 

Platelet secretion: Control mechanisms and role in thrombosis, cardiac damage and repair (renewal) 

5 years 

£1,537,451

RG/15/17/31749                                  

Professor Mark Hanson et al.

Southampton, University of 

Epigenetic Biomarkers and Determinants of Cardiovascular Risk in Children 

5 years 

£1,179,307


PG/15/53/31371 

Dr Sebastian Oltean et al.

Bristol, University of 

mRNA splicing control in diabetes: a novel therapeutic strategy for treatment of diabetic nephropathy 

3 years 

£268,270

PG/15/54/31559 

Professor Paolo Madeddu

Bristol, University of 

Longevity-associated BPIFB4 gene therapy for treatment of ischemic disease 

3 years 

£219,503


PG/15/55/31568 

Dr Andrew F James et al.

Bristol, University of 

Selective late sodium current blockers as antiarrhythmic drugs in atrial fibrillation 

3 years 

£226,944

PG/15/56/31573 

Dr Gregory Quinlan et al.

Imperial College London  

The disrupted hepcidin/ferroportin axis and proliferative responses in pulmonary arterial hypertension 

3 years 

£294,534


PG/15/57/31580 

Professor Steven Ley et al.

National Institute for Medical Research 

Regulation of atherosclerosis by TPL-2 kinase 3 years 

£258,466


PG/15/58/31611 

Dr Bill Chaudhry et al.

Newcastle upon Tyne University of 

Zebrafish to dissect the role of jnk1 in cardiac development 

3 years 

£252,850


PG/15/59/31621 

Dr Emmanuel Dupont et al.

Imperial College London  

An In silico model of action potential propagation, biologically validated in the HL1-6 myocyte cell line:  A framework for characterising myocardial re-entry and fibrillation in the human heart 

3 years 

£296,235


PG/15/60/31629 

Dr Ran Yan et al.

King's College London 

Development of novel 

18F-PET tracers for direct detection of myocardial oxidative stress in cardiovascular disease 

3 years 

£262,527


PG/15/61/31634 

Dr Martina E Daly et al.

Sheffield, University of Identification and characterisation of FLI1 and RUNX1 regulated determinants of platelet granule biogenesis and secretion 

3 years 

£194,647


PG/15/62/31653 

Dr Stephen Wheatcroft et al.

Leeds, University of

Increasing IGFBP1 levels as a strategy to promote therapeutic angiogenesis in diabetes 

3 years 

£222,000


PG/15/63/31659 

Professor Margaret MacLean et al.

Glasgow, University of 

Investigating oestrogen metabolism in pulmonary artery smooth muscle cells 

2 years 

£176,845


PG/15/64/31681 

Dr Jacob George et al.

Dundee, University of

Vascular Effects of Smoking Usual cigarettes Versus electronIc cigaretteS(VESUVIUS) 

2 years 9 months 

£199,368


PG/15/65/31707 

Professor Nicholas Brindle et al.

Leicester, University of 

An angiopoietin-2-specific ligand-trap with potential to treat cardiovascular disease 

3 years 

£198,173


PG/15/66/31710 

Professor M-Saadeh Suleiman et al.

Bristol, University of 

Role of cyclic AMP/PKA/Epac signalling in cardioprotection 

2 years 

£169,119


PG/15/67/31715 

Professor Houman Ashrafian et al.

Oxford, University of 

Adenosine A2A receptors in myocardial fibrosis 

2 years 

£207,329


PG/15/68/31717 

Dr Maarten Koeners et al.

Bristol, University of 

Carotid body-renal interactions in renovascular hypertension 

3 years 

£265,526


PG/15/69/31719 

Dr Beata J Wojciak Stothard et al.

Imperial College London 

Role of endothelial clic4 in the regulation of pulmonary vascular remodelling in pulmonary hypertension 

2 years 

£173,452


PG/15/70/31724 

Professor Andrew Trafford et al.

Manchester, University of 

Investigating the role of Amphiphysin II (BIN1) in the control of cardiac t-tubule biogenesis and function 

3 years 

£234,436


PG/15/71/31731 

Dr Stefan Piechnik et al.

Oxford, University of

Analysis of diffuse fibrosis with T1 mapping in the CMR in Hypertrophic Cardiomyopathy (HCMR) Study 

3 years 

£287,133


PG/15/72/31732 

Dr Thomas Nightingale et al.

Queen Mary, University of London 

An investigation into novel regulatory mechanisms for Von Willebrand factor secretion from endothelial cells 3 years 

£197,752


PG/15/73/31743 

Dr Stephen Wheatcroft et al.

Leeds, University of 

Examining the mechanisms underpinning protection from atherosclerosis in mice with increased endothelial cell insulin-like growth factor-1 receptor expression 

3 years 

£267,233


PG/15/74/31747 

Dr Luca Biasiolli et al.

Oxford, University of 

Clinical MRI of carotid atherosclerosis using T2 mapping: development and validation of novel methods for plaque lipid quantification 

3 years 

£204,611


PG/15/75/31748 

Dr Ashraf William Khir et al.

Brunel University London 

The determination of local arterial stiffness and left ventricular load: a new non-invasive technique for calculating PWV and wave intensity 

3 years 

£264,511

PG/15/76/31756 

Professor Ziad Mallat

Cambridge, University of 

Marginal zone B cells and the regulation of the pro-atherogenic T follicular helper response 

2 years 

£201,386


PG/15/77/31761 

Professor Andrea E Munsterberg

East Anglia, University of 

Signaling cross-talk regulating migration and fate choice in cardiac progenitor cells 

3 years 

£182,012


PG/15/78/31771 

Professor Gurtej K Dhoot et al.

Royal Veterinary College, University of London 

Mechanism of Sulf1/Sulf2 functionin cardiovascular development and myocardial repair 

3 years 

£213,324


PG/15/79/31777 

Professor Timothy Warner et al.

Queen Mary, University of London 

Control of thrombosis by endogenous pathways of platelet inhibition and relevance to anti-platelet therapy 

3 years 

£233,827


PG/15/80/31781 

Dr Krishnan Bhaskaran et al.

London School of Hygiene and Tropical Medicine

Impact of the media interest in side effects on the initiation and cessation of statins in the UK 

1 year 

£55,099


Clinical Studies

CS/15/7/31679 

Dr Vijay Kunadian et al 

The OLDer Patients Randomised Interventional Trial in Acute Non-ST Elevation Myocardial Infarction:The OLD-RITA Trial

5 years 

£1,705,737


CS/15/8/32065                                  

Professor Keith Muir

Glasgow, University of 

Sixth Joint Stroke Association/BHF Clinical Study: Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis 

5 years 

£750,000


Translational Grants

TG/15/3/31692                                  

Professor Adrian Hobbs et al.

Lead optimisation of novel small molecule natriuretic peptide receptor (NPR)-C agonists for the treatment of myocardial infarction 2 years £396,422

TG/15/4/31891                                  

Dr Geoffrey Moggridge et al.

A Novel Transcatheter Valve for Younger Patients with Aortic Stenosis 1.5 years £248,018


4 year PhD Studentships 

FS/15/62/32032 

Professor Martin Bennett

University of Cambridge 

Cambridge 3rd intake 2015 4 Year PhD Studentship (3rd) Scheme: Ms Sarah Burgess; Ms Sophie McManus; Mr Joshua Hodgson; Ms Annabel Taylor 

£627,196 


FS/15/63/32033 

Dr Matthew Bailey

University of Edinburgh 

Edinburgh 3rd intake 2015 4 Year PhD Studentship (3rd) Scheme: Ms Sarah Finnie; Ms Natalie Jones; Ms Charlott Repschlager; Ms Kathleen Scullion 

£596,156


FS/15/64/32035 

Professor Rhian Touyz

University of Glasgow 

Glasgow 3rd intake 2015 4 Year PhD Studentship (3rd) Scheme: Ms Aisling McFall; Ms Sarah McNeilly; Ms Alexandra Riddell; Ms Francesca Vidler 

£576,920 


FS/15/65/32036 

Professor Sian Harding

Imperial College London 

Imperial 3rd intake 2015 4 Year PhD Studentship (3rd) Scheme: Ms Adela Constantinescu; Mr Jerome Fourre; Ms Alveera Hasan; Ms Viktoria Kalna 

£642,196 


FS/15/66/32037 

Professor Metin Avkiran

King's College London

KCL 3rd intake 2015 4 Year PhD Studentship (3rd) Scheme: Ms Grace Anderson; Mr Sean Burnap; Ms Ailbhe O’Brien; Ms Ms Meredith Whitehead 

£630,136 


FS/15/67/32038 

Dr Elizabeth Cartwright

University of Manchester 

Manchester 3rd intake 2015 4 Year PhD Studentship Scheme: Ms Lorenz Becker; Ms Elisavet Fotiou; Ms Miriam Lettieri; Ms Damilola Olubando 

£578,016 


FS/15/68/32042 

Professor David Greaves

University of Oxford 

Oxford 3rd intake 2015 4 Year PhD Studentship (3rd) Scheme: Ms Kathryn Acheson; Mr Matthew Kerr; Mr Hamish Lemmey; Ms Irina Lupu 

£626,180 


FS/15/69/32043 

Professor Timothy Warner

Queen Mary, University of London 

QMUL 3rd intake 2015 4 Year PhD Studentship (3rd) Scheme: Ms Lauren Callender; Ms Alice Hamilton; Ms Eithne Maguire; Mr Michael Preedy 

£619,312 


FS/15/70/32044 

Professor Peter Scambler

University College London

UCL 3rd intake 2015 4 Year PhD Studentship (3rd) Scheme: Mr Daniel Aggio; Ms Rebecca Bolton; Ms Kirsty Naylor; Ms Kaloyan Takov 

£627,244 


PhD Studentships 

FS/15/71/31677 

Professor Stephen P Watson

University of Birmingham

(Mr. Alex Hardy) 

The regulation and role of Syk phosphorylation by platelet glycoprotein receptors 

2 years 

£73,020 


FS/15/72/31676 

Professor Asif Ahmed 

Aston University 

(Miss Athina Georgiadou)

An investigation of the impact of soluble Flt-1 and soluble endoglin-induced sensitisation of the endothelium to pro-inflammatory cytokines to promote preeclampsia 

3 years 

£107,160 


FS/15/73/31672 

Professor Shamshad Cockcroft 

University College London

(Mr. Nicholas Blunsom) 

Regulation of the rate-limiting enzyme, CDP-diacylglycerol synthase (CDS) in mitochondrial biogenesis in cardiomyocytes 

3 years 

£123,214 


FS/15/74/31669 

Dr Lingfang Zeng 

King's College London 

(Mr. Bijaya Shrestha) 

The role of the endothelial cell differentiation-related LAF4IR in vascular repair 

3 years 

£116,384 


FS/15/75/31688 

Professor David Middleton 

Lancaster University 

(Miss Sophie Lau)

The structure-function relationship of enhanced cardioprotective apolipoprotein A-I mutants in high density lipoprotein nanoparticles 

3 years 

£105,187 


FS/15/76/31720 

Professor Timothy Palmer 

University of Bradford

(Ms Ellanor Whiteley)

Prostanoid-mediated Inhibition of IL-6 Trans-Signalling in Pulmonary Arterial Hypertension; a Role for Epac1-Mediated Induction of "Suppressor of Cytokine Signalling 3" (SOCS3) 

3 years 

£106,986 


FS/15/77/31823 

Professor Ioakim Spyridopoulos 

University of Newcastle

(Mr. Emanuele Andreano)

Lymphocyte Activation and Transmigration Through the CX3CL1/CX3CR1 Axis During Myocardial Ischemia/Reperfusion 

3 years 

£122,928 


Clinical Research Training Fellowships

FS/15/78/31678

Dr Divaka Perera 

King's College London 

(Dr Bhavik Modi) 

Fractional flow reserve in serial and diffuse coronary artery disease 

3 years 

£211,153 


FS/15/79/31736 

Mr. Prakash P Punjabi 

Imperial College London  

(Miss Amina Khalil) 

Characterisation of chamber-specific fibroblasts from adult human heart and investigation of their potential contribution to the function of engineered heart tissue 

2 years 

£152,776 


FS/15/80/31803 

Dr Oliver Rider 

University of Oxford

(Dr Mark Peterzan) 

The role of myocardial ATP delivery rates in myocardial hypertrophy 

3 years 

£271,941


FS/15/81/31817 

Professor Stuart Cook 

Imperial College London 

(Dr Catherine Francis) 

Genetic determinants of aortic morphology and function 

2.5 years 

£159,463 


FS/15/82/31824 

Professor Robert Storey 

University of Sheffield

(Dr Wael Sumaya) 

The fibrin network and clinical outcomes in patients with acute coronary syndrome: An additional therapeutic target? 

3 years 

£213,387