December 2014 - New Grants

Lab gear We’ve awarded six new Intermediate Fellowships since the last newsletter. These talented researchers have diverse interests from investigating iron deficiency in people with chronic heart failure to exploring redox signalling pathways in disease. 

Read on to find out more about the grants we've recently awarded.


Project Grants

PG/14/49/30876
Professor Sarah Jane George et al.
University of Bristol
Translational potential of N-cadherin peptide mimics for reducing intimal thickening 3 years
£131,781

PG/14/50/30891
Prof Rustam Al Shahi Salman et al.
University of Edinburgh
PRIME-RESTART: Promoting Recruitment using Information Management Efficiently (PRIME) for randomised controlled trials of secondary prevention after stroke, piloted using the REstart or STop Antithrombotics Randomised Trial (RESTART)
2 years
£109,321

PG/14/51/30686
Dr Philip E James et al.
Cardiff University
Extracellular vesicle transport in the circulation – a missing link between adipocytes and accelerated vascular dysfunction
3 years
£226,891

PG/14/52/30873
Professor Philip Chowienczyk et al.
King's College London
Mechanisms leading to an impairment of vascular homeostasis during acute stress: interaction between sympathetic activity and neuronal nitric oxide synthase
3 years
£198,117

PG/14/53/30900
Dr Susan Pyner
University of Durham
Molecular characterisation of atrial volume receptors in the atria of the rat heart
3 years
£177,614

PG/14/54/30939
Professor Mark Kearney et al.
University of Leeds
Targeting Nox2 NADPH oxidase in insulin resistance related atherosclerosis and oxidative stress
3 years
£277,837

PG/14/55/30973
Dr Caroline Dart et al.
University of Liverpool
Towards understanding cAMP signalling in the vasculature: spatio-temporal activation of PKA and Epac by physiological vasodilators
3 years
£182,478

PG/14/56/30976
Professor James Scott et al.
Imperial College London
The role of perturbed nitric oxide signalling in disruption of the neurovascular unit of the blood brain barrier by environmental and genetic risk factors for Alzheimer’s disease
3 years
£259,115

PG/14/57/30992
Professor Iain A Greenwood et al.
St George's, University of London
Defining the role of phosphatidyl 4, 5 bisphosphate on arterial calcium-activated chloride channels
3 years
£189,585

PG/14/58/30998
Professor Kim A Dora et al.
Oxford, University of
Investigation of endothelial cell signalling in freshly isolated tubes
3 years
£169,776

PG/14/59/31000
Professor Chris Denning et al.
University of Nottingham
Deep molecular phenotyping of myotonic dystrophy (DM1) hiPSC-cardiomyocytes to facilitate risk stratification and drug evaluation
3 years
£299,933

PG/14/60/31014
Professor Jeremy Henley et al.
University of Bristol
Protective mechanisms of protein SUMOylation in the heart
3 years
£282,650

PG/14/61/31015
Professor Jules Hancox et al.
University of Bristol
New pathogenic mechanisms in the long QT syndrome: KCNE1 modulation of hERG
2 years 6 months
£186,836

PG/14/62/31034
Professor Sussan Nourshargh et al.
Queen Mary, University of London
An investigation into the role of TNF in neutrophil-mediated microvascular plasma protein leakage
3 years
£215,864

PG/14/63/31036
Dr Josefin Ahnstrom et al.
Imperial College London
Factor V as a synergistic cofactor together with protein S in the inhibition of FXa by TFPI
3 years
£198,242

PG/14/64/31043
Professor Colin Berry et al.
University of Glasgow
First steps towards computed modelling of myocardial infarction (an MI Physiome): A case-control study of novel biomechanical parameters in acute MI survivors with left ventricular dysfunction
2 years
£104,456

PG/14/65/31055
Professor Clive Orchard et al.
University of Bristol
Role of cardiac T-tubules in Ca regulation and arrhythmogenesis
3 years
£155,799

PG/14/66/30927
Dr Martin Bishop et al.
King's College London
Investigating the mechanisms of low-voltage defibrillation and its application to the human ventricle to facilitate its translation into the clinic
2 years
£161,287

PG/14/67/31030
Professor Sarah Jane George et al.
University of Bristol
Role of WISP-1 (CCN4) in aneurysms
3 years
£129,336

Fellowships

Non-Clinical Fellowships

Intermediate Basic Science Research Fellowship

FS/14/55/30806
Dr Jemma Hopewell 
University of Oxford
Pharmacogenomic, genetic and trial-based studies of lipid-modifying therapies and vascular risk
4 years
£652,425

FS/14/56/31049
Dr Mark Crabtree 
University of Oxford
Novel approaches to discover new NO-redox signalling targets in cardiovascular disease
4 years
£485,280

FS/14/57/31138
Dr Olena Rudyk 
King's College London
Does redox state of PKG1α control hypoxic vasoconstriction and remodelling in the pulmonary vasculature?
4 years
£379,870

Travel Fellowships

FS/14/58/30979
Dr Jonathan Moore
Bangor University
Mechanisms of sympathoexcitation in humans
6 months
£7,845

4 year PhD Studentships

FS/14/59/31282
Professor Martin Bennett
University of Cambridge
Cambridge 2nd intake 2014 4 Year PhD Studentship (3rd) Scheme: Ms Jessica Beeson; Mr Ross Lindsay; Mr Cai Read; Ms Jessica Rees (4 years)
4 years
£623,584

FS/14/60/31283
Dr Matthew Bailey
University of Edinburgh
Edinburgh 2nd intake 2014 4 Year PhD Studentship (3rd) Scheme: Mr Benjamin Cathcart; Ms Marie-Louise Monaghan; Ms Bonnie Nicholson; Mr Richard Sulston (4 years)
4 years
£594,936

FS/14/61/31284
Professor Rhian Touyz
University of Glasgow
Glasgow 2nd intake 2014 4 Year PhD Studentship (3rd) Scheme: Ms Stephanie Anderson; Mr Peter Bowman; Ms Sinead Griffin; Mr Quentin Lachaud (4 years)
 4 years
£576,592

FS/14/62/31288
Professor Sian Harding
Imperial College London
Imperial 2nd intake 2014 4 Year PhD Studentship (3rd) Scheme: Ms Navneet Bhogal; Ms Ana Lima; Ms Laura Moody; Ms Sara Samari (4 years)
4 years
£639,616

FS/14/63/31290
Professor Metin Avkiran
King's College London
KCL 2nd intake 2014 4 Year PhD Studentship (3rd) Scheme: Ms Joy Askew; Mr Marc Lynch; Ms Jennifer Mitchell; Ms Natalie Savage (4 years)
4 years
£628,404

FS/14/64/31291
Dr Elizabeth Cartwright
University of Manchester
Manchester 2nd intake 2014 4 Year PhD Studentship Scheme: Mr Ben Clark; Ms Fatemah Jafarzadeh; Ms Kirsty Webb; Ms Violeta Trendafilova (4 years)
4 years
£577,336

FS/14/65/31292
Professor David R Greaves
University of Oxford
Oxford 2nd intake 2014 4 Year PhD Studentship (3rd) Scheme: Ms Jade Bailey; Ms Maria Sousa Fialho; Ms Laurienne Gardner; Ms Matilde Stefanini (4 years)
4 years
£627,276

FS/14/66/31293
Professor Timothy Warner
Queen Mary, University of London
QMUL 2nd intake 2014 4 Year PhD Studentship (3rd) Scheme: Mr Matthew Dukinfield; Ms Olga Giannakopoulou; Ms Claire MacDougall; Ms Eleanor Ward (4 years)
4 years
£617,308

FS/14/67/31294
Professor Peter Scambler
University College London
UCL 2nd intake 2014 4 Year PhD Studentship (3rd) Scheme: Ms Eseelle Hendow; Ms Samantha Lawes; Ms Ariadna Navarro Aragall; Ms Stasa Taferner (4 years)
4 years
£626,196

PhD Studentships

FS/14/68/30988
Dr William Fuller
University of Dundee
Characterisation of the cardiac palmitoyl transferase DHHC5
3 years
£109,439

FS/14/69/31001
Dr Samantha Pitt (Mr. Gavin Robertson)
University of St Andrews
Understanding new mechanisms of cardiac ryanodine receptor regulation by zinc
3 years
£107,172

FS/14/70/31006
Dr Emmanuel Pinteaux (Miss Ivana Rajkovic)
University of Manchester
The role of the acute phase protein pentraxin-3 in vascular inflammation and angiogenesis after cerebrovascular disease  
3 years
£117,443

FS/14/71/31038
Dr Paul Kemp (Mr. Henry Li)
Imperial College London 
MicroRNAs, GDF-15 and myostatin regulate skeletal muscle mass in chronic heart failure and pulmonary arterial hypertension
3 years
£122,878

FS/14/72/31067
Professor Jennifer Potts
University of York
Structural analysis of SasC, a repetitive staphylococcal biofilm-forming protein implicated in antibiotic resistance
3 years
£107,263

FS/14/73/31107
Dr Mathilda Mommersteeg (Miss Abigail Killen)
University of Oxford
Epicardial fat: a duplicitous role during heart regeneration?
3 years
£114,458

FS/14/74/31121
Professor Sarah Jane George (Mr. Steven Simmonds)
University of Bristol
Regulation of foam cell formation, apoptosis and proliferation by Wnt signalling: implications for atherosclerosis
1 year, 9 months
£66,435

FS/14/75/31134
Professor Morris J Brown (Ms Sumedha Garg)
University of Cambridge
Do somatic mutations of an L-type Ca++ channel in aldosterone-producing adenomas of the adrenal indicate a novel mechanism and target for regulating aldosterone production?
3 years
£124,742

Clinical Fellowships

Intermediate Clinical Research Fellowships

FS/14/76/30933
Dr Riyaz Patel 
University College London
Genetic and phenotypic risk factors for subsequent coronary heart disease events
4 years
£504,977

FS/14/77/30913
Dr Darlington Okonko 
King's College London
Strategies for Optimal Iron Repletion in Chronic Heart Failure and the Mechanisms of Benefit
4 years
£844,817

FS/14/78/31020
Dr Marc Dweck 
University of Edinburgh
Modification of calcification activity and 18F-Fluoride positron emission tomography uptake in cardiovascular disease
5 years
£976,514

Infrastructure Grants

IG/14/3/31171                                  
Professor Peter Scambler et al.
University College London
Funding towards a multiphoton confocal microscope
1 year
£80,000

IG/14/4/31172                                  
Professor Manuel Mayr et al.
King's College London
Funding towards equipment for the Cardiovascular Proteomics Facility
1 year
£676,416

New Horizons Grants

NH/14/2/31074                                  
Dr Jonathan Taylor et al.
University of Glasgow
Development and optimisation of synchronised 3D in-vivo imaging of the embryonic and juvenile zebrafish heart
3 years
£162,279

Special Projects

SP/14/3/31114                                  
Professor Jane Armitage et al.
University of Oxford
ASCEND: A Study of Cardiovascular Events in Diabetes
4 years
£1,078,533

SP/14/4/31123                                  

Professor Russell Jago et al. University of Bristol The influence of families and friends on change in physical activity, sedentary behaviour and screen-viewing from Years 1 to 6 in the B-PROACT1V cohort: Finding new ways to change behaviour 4 years, 6 months £538,547

SP/14/5/31349                                  
Professor Brian Davidson
University College London
UKCRC Joint Funders Tissue Directory and Coordination Centre (Joint funding with MRC)
3 years
£100,000

SP/14/6/31350                                  
Professor James Wild
University of Sheffield
POLARIS: Pulmonary, Lung and Respiratory Imaging Sheffield (Joint funding with MRC)
1 year
£963,167

SP/14/7/31351                                  
Professor Sven Plein
University of Leeds
Translational Hyperpolarised Magnetic Resonance (Joint funding with MRC)
1 year
£536,833

SP/14/8/31352                                  
Professor Philip Chowienczyk
King's College London, St Thomas' Hospital
Ancestry and biological Informative Markers for stratification of HYpertension: The AIM HY study (Joint funding with MRC)
5 years
£1,100,174

Programme Grants

RG/14/5/30893                                  
Professor Panos Deloukas et al.
Barts and the London School of Medicine and Dentistry
Genomics of Coronary Artery Disease
4 years, 6 months
£1,116,309

RG/14/6/31144                                  
Professor Qingbo Xu et al.
King's College London Vascular Resident Stem Cells in Arteriosclerosis (renewal)
5 years
£1,122,687

Clinical Study Grants

CS/14/4/30972                                  
Professor Philip Bath et al.
Nottingham, University of
Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2): Assessment of safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor, and of the feasibility of a multicentre ambulance-based stroke trial.  
3 years
£1,370,708