August 2015 - New grants

Lab gear

Since the last newsletter, we have a new Cardiff based Senior Basic Science Research Fellow, Dr Spryos Zissimopoulos. 

He studies the ryanodine receptor - the large channel that releases calcium inside heart muscle cells - asking if the channel’s structure is altered in heart disease and if drugs can be used to return it to normal.

See who else has a new grant. 

Fellowships

Senior Basic Science Research Fellowship

FS/15/30/31494
Dr Spyros Zissimopoulos
Cardiff University
Drug-induced stabilisation of RyR2 to improve calcium handling and cardiac function in arrhythmogenic cardiac disease
5 years
£1,026,035 

Intermediate Basic Science Research Fellowship

FS/15/31/31418
Dr Elizabeth Cottrell
University of Manchester
Dietary constituents as pregnancy therapeutics: can dietary nitrate improve vascular function and growth in fetal growth restriction?
4 years
£591,890

FS/15/32/31604
Dr Hiten Mistry 
University of Nottingham
A new approach to an old problem: The roles of aldosterone and salt in normal pregnancy and pre-eclampsia
4 years
£478,876

FS/15/33/31608
Dr Daniel Stuckey 
University College London
Image guided cardiac regeneration: Visible biomaterials functionalised to enhance stem cell-mediated repair and improve cardiac function
4 years
£379,561

FS/15/34/31656
Dr Peter Scarborough
University of Oxford
Predicting cardiovascular disease rates in England using novel mathematical models
4 years
£421,085 

Non-Clinical PhD Studentships

FS/15/36/31525
Dr Simon Calaminus 
University of Hull
Mr. Lloyd Atkinson - Platelet cAMPsignaling controls thrombosis through enhanced embolisation
3 years
£106,468

FS/15/37/31513
Professor Robert A S Ariens
University of Leeds
Mr. Nathan Asquith - Role of extended knob-hole interaction sites in fibrin polymerisation and clot stability
3 years
£107,059 

FS/15/38/31516
Dr Helle F Jorgensen
University of Cambridge
Miss Jennifer Harman - Functional analysis of H3K9-methylation on gene regulation and phenotypic switching in vascular smooth muscle cells
3 years
£117,436 

FS/15/39/31526
Dr Pia Ostergaard
St George's, University of London
Miss Elisavet Fotiou - Functional studies on the EphB4 signalling pathway in patients with generalised lymphatic dysplasia
3 years
£130,381

FS/15/40/31536
Dr Ramzi Ajjan
University of Leeds
Miss Katherine Kearney - Artificial binding proteins for the targeted modulation of fibrin-related thrombosis risk
3 years
£103,889

FS/15/41/31564
Professor Andrea E Munsterberg 
University of East Anglia
Investigating a microRNA-Ets1 network during endocardial cushion development
3 years
£104,285

FS/15/42/31556
Dr Alan Stewart 
University of St Andrews
Characterisation of zinc-dependent heparin neutralisation by fibrinogen and histidine-rich glycoprotein
3 years
£107,346

FS/15/43/31565
Professor Peter Shaw 
University of Nottingham
Mr. Tom Halliwell - Linking STAT3 redox control to oxidative stress-responsive gene regulation, cell survival and ischaemic preconditioning
3 years
£113,079

FS/15/44/31570
Dr Anthony Albert 
St George's, University of London 
Miss Kazi Jahan - Role of the PIP2-binding protein MARCKS on voltage-gated Ca2+ channels and vascular contractility
3 years
£114,469

FS/15/45/31603
Professor Valerie O'Donnell
Cardiff University
Mr. Christopher Brasher - Defining the platelet lipidome in cardiovascular disease in humans and mice
3 years
£96,812 

FS/15/46/31606
Dr Francisco Rivero 
University of Hull
Coronin is a negative regulator of platelet spreading and thrombus formation
3 years
£106,915

FS/15/47/31646
Professor Catherine M Shanahan 
King's College London 
Ms Sofia Tsakali - A role for mechano-signalling in vascular calcification
3 years
£116,228

FS/15/48/31665
Dr Neil Turner 
University of Leeds
Miss Nicola Blythe - Investigating the role of the mechanosensitive cation channel Piezo1 in the regulation of cardiac fibroblast function
3 years
£107,674

Clinical Fellowships

Intermediate Clinical Research Fellowships

FS/15/49/31612
Mr. Nigel Drury 
University of Birmingham
Remote Ischaemic Preconditioning for myocardial protection in young children undergoing heart surgery: a double-blind, randomised controlled trial in normoxic and hypoxic patients
4 years
£468,325

Clinical Research Training Fellowship

FS/15/50/31500
Dr Rachel Myles 
University of Glasgow
Dr Cherry Alexander - The role of sarcoplasmic reticulum calcium in the generation of early after-depolarisations and ventricular arrhythmias in the long QT syndrome
3 years
£181,204

FS/15/51/31503
Professor Federica Marelli Berg 
Queen Mary, University of London 
Dr Lucia Grosso Di Palma - Novel molecular targets for the diagnosis and treatment of myocarditis
3 years
£192,094

FS/15/52/31587
Professor Simon Redwood
King's College London
Dr Jubin Joseph - Investigating the haemodynamic and physiological principles underlying exercise induced angina, and glyceryl trinitrates anti-anginal effect, using invasive coronary and ventricular measures of coronary flow and cardiac work
3 years
£230,305

FS/15/53/31615
Dr Zachary Whinnett
Imperial College London 
Dr Daniel Keene - Investigation of the physiological mechanisms through which Ventricular Tachycardia (VT) impairs cardiac function and exploration of potential clinical applicable therapy to improve cardiac output during VT
3 years
£201,066

FS/15/54/31639
Professor Colin Berry 
University of Glasgow
Dr Kenneth Mangion - Myocardial strain measurements in survivors of acute ST elevation myocardial infarction: implementation and prognostic significance of novel magnetic resonance imaging methods
2 years
£117,075 

FS/15/55/31649
Professor Serena Counsell 
King's College London 
Dr Christopher Kelly - The relation of cerebral oxygen delivery to brain dysmaturation and damage in infants with congenital heart disease
3 years
£210,218 

Clinical PhD Studentships

FS/15/35/31529 
Professor Cesare M N Terracciano
Imperial College London
Mr. Samuel Watson - Training strategies for the development and maintenance of mature structural and electromechanical properties of cardiac muscle patches in vitro 
3 years 
£119,132 

Project Grants

PG/15/34/31300
Dr Gillian Douglas et al.
University of Oxford
The Role of Abcg1 in Atherosclerotic Plaque Regression
1 year
£52,856 

PG/15/35/31403
Professor Keith Channon et al.
University of Oxford
Effects of KIAA1462, a new causal CAD gene, in atherosclerosis
3 years
£247,941 

PG/15/36/31425
Dr Prapa Kanagaratnam et al.
Imperial College London
Ablation versus anti-arrhythmic therapy for reducing all hospital episodes from recurrent atrial fibrillation
2 years 6 months
£258,368 

PG/15/37/31438
Dr Kenton Arkill et al.
University of Nottingham
Novel nanosensors for real time determination of shear stress experienced by the endothelial surface layer – development, validation, and use in growing vasculature
1 year 6 months
£113,822 

PG/15/38/31466
Prof Catherine M Shanahan et al.
King's College London
Novel role for poly(ADP)ribose in vascular calcification
3 years
£290,798 

PG/15/39/31519
Dr Wei Li et al.
University of Cambridge
Development of non-osteogenic variants of bone morphogenetic protein 9 as novel therapies for pulmonary arterial hypertension
2 years
£131,534 

PG/15/40/31522
Dr Giordano Pula et al.
University of Bath
Characterisation of the role of NADPH oxidase 1 in collagen-dependent activation of platelets: a potential target for the development of novel antithrombotics?
3 years
£219,776 

PG/15/41/31560
Professor Angela Clerk
University of Reading
Regulation of the Germinal Centre Kinase (GCK) MST3 by STRiatin-Interacting Phosphatase And Kinase (STRIPAK) complexes
1 year 6 months
£145,596 

PG/15/42/31563
Dr William Fuller et al.
University of Dundee
Cavins: mobile regulators of β-adrenoceptor signalling in the cardiac cell
3 years
£185,061 

PG/15/43/31567
Professor Sarah Jane George et al.
University of Bristol
Wnt protein activation by periodontal bacteria: implications for atherosclerosis
3 years
£174,277 

PG/15/44/31574
Professor Michael L J Ashford et al.
University of Dundee 
BACE1 and endothelial dysfunction in diabetes
3 years
£289,872 

PG/15/45/31579
Dr James P Fisher et al.
University of Birmingham
Cerebral vasomotor regulation in atrial fibrillation
2 years
£155,944 

PG/15/46/31589
Professor Deborah Henderson et al.
University of Newcastle upon Tyne 
Lineage relationships in aortic valve development
3 years
£268,501 

PG/15/47/31591
Professor Timothy Warner et al.
Queen Mary, University of London
Platelet response phenotyping to improve anti-thrombotic therapy
3 years
£217,121 

PG/15/48/31592
Professor Chris Peers et al.
University of Leeds
Regulation of Cav3.1 T-type calcium channels by heme oxygenase-1 derived carbon monoxide: a novel target signalling pathway for the treatment of vascular diseases
3 years
£253,169 

PG/15/49/31595
Professor Rob Krams et al.
Imperial College London
Disturbed shear stress and strain act synergistically to promote the pro-atherogenic endothelial cell phenotype responsible for TCFA
3 years
£299,991 

PG/15/50/31594
Dr Mathilda Mommersteeg et al.
University of Oxford
Exploring the role of Slit-Robo signalling in cardiac innervation
3 years
£279,569 

PG/15/51/31596
Dr Nicholas Mills et al.
University of Edinburgh
High-Sensitivity Cardiac Troponin On Presentation to Rule Out Myocardial Infarction (HiSTORIC)
3 years
£271,484 

PG/15/52/31598
Dr Sean Davidson et al.
University College London
Novel means of cardioprotection by exploiting pathways activated by Stromal Derived Factor-1α
3 years
£282,121 

Programme Grants 

RG/15/6/31436                              
Professor Alan Williams et al.
Cardiff University
Predicting anti-arrhythmic drug efficacy from the divergent molecular basis of RyR2 dysfunction in genetic arrhythmia syndromes (renewal)
5 years
£995,228 

RG/15/7/31521                                  
Professor Mark Kearney et al.
University of Leeds 
Manipulating insulin like growth factor-1 and hybrid receptor expression as a therapeutic strategy to control insulin sensitivity and cardiovascular repair (renewal)
5 years
£1,376,166 

RG/15/8/31480                                  
Professor Mathias Gautel et al.
King's College London
A comprehensive approach to the genetic, molecular and functional impact of rare titin variants in hypertrophic cardiomyopathy
5 years
£1,159,309 

RG/15/9/31534                                  
Professor Richard Vaughan-Jones et al.
University of Oxford 
H+ ion control and signalling in cardiac hypertrophy and heart failure (renewal)
5 years
£1,176,355

RG/15/10/31485                                  
Professor David Greaves et al.
University of Oxford 
Recruitment, Proliferation and Differentiation of Monocyte/ Macrophages in Cardiovascular Inflammation and Repair (renewal)
5 years 
£1,173,882 

RG/15/11/31593                                  
Professor Ziad Mallat
University of Cambridge
Defining the role(s) of selective subsets of antigen presenting cells in promoting or preventing atherosclerosis (renewal) 
5 years 
£1,730,669 

RG/15/12/31616                                  
Professor Bernard Keavney et al.
University of Manchester
Investigation of genetic mechanisms underlying susceptibility to complex congenital and arrhythmic cardiovascular disease (renewal) 
5 years 
£1,129,185 

RG/15/13/31673                                  
Professor Yotis Senis et al.
University of Birmingham
Regulation of platelet homeostasis and thrombosis by the kinase-phosphatase pair Csk-CD148 
5 years 
£966,132  

Special Projects

SP/15/5/31548                                  
Dr Geoffrey Moggridge et al.
University of Cambridge,
A Polymeric Prosthetic Heart Valve from anisotropic nanocomposites – device optimisation and in vivo testing
4 years
£755,030 

SP/15/6/31397
Dr Mark Hamer et al.
Loughborough University 
Objective assessment of free-living physical activity and sedentary in the 1970 British Cohort Study (BCS70) 
3 years
£522,485 

SP/15/7/31561                                 
Professor Richard Farndale et al.
University of Cambridge
Integrated collagen patches for cardiac repair:Engineering vascularised cardiac tissue from microporous collagen scaffolds, cell attachment peptides and human embryonic stem cells
4 years 
£798,506 

SP/15/8/31575                                  
Dr Mark  Miller et al.
University of Edinburgh, 
Eicosanoids as Mediators of Nanoparticle-Induced Cardiovascular Disease 
3 years 
£538,064 

SP/15/9/31605                                  
Professor Chris Denning et al.
University of Nottingham
Coupling gene targeted reporters with fully automated compound library screening to mature hPSC-cardiomyocytes 
4 years 
£1,074,373 

Clinical Studies   

CS/15/3/31405                                  
Dr Zachary Whinnett et al.
Imperial College London 
AV optimisation delivered with direct His bundle pacing, in patients with heart failure, long PR without left bundle branch block: randomised multi-centre clinical outcome studyThe His Optimised Pacing Evaluated for Heart Failure Trial (HOPE-HF) 
3 years, 9 months 
£962,958 

CS/15/4/31493                                  
Professor Caroline Fall et al.
University of Southampton
Childhood and young adult predictors of myocardial structure and function at age 45 years in the New Delhi and Vellore Birth Cohorts, India 
3 years 
£653,954 

CS/15/5/31475                                  
Professor Joanna Wardlaw et al.
University of Edinburgh 
LACunar Intervention (LACI) Trial: Assessment of safety and efficacy of cilostazol and isosorbide mononitrate to prevent recurrent lacunar stroke and progression of cerebral small vessel disease 
3 years 
£847,771

CS/15/6/31468                                  
Professor Alun Hughes et al.
University College London
Study of Emerging Adulthood and Cardiometabolic Health in ALSPAC: the iNfluence of Growth and other Exposures (SEA CHANGE) 
4 years, 10 months 
£999,049 

Translational Grants

TG/15/1/31518                                  
Professor Michael S Marber et al.
Comparing the Diagnostic and Prognostic Performance of Myosin Binding Protein C to Troponin I and Troponin T in Patients Presenting with Chest Pain 
£204,522 

TG/15/2/31691                                  
Dr James Leiper et al.
Medical Research Council 
Translation of a novel compound that improves outcomes in sepsis into humans 
6 months 
£91,768

Strategic Initiatives

SI/15/1/30552
Professor Paul Riley
University of Oxford 
Funding towards a new Oxford Institute of Developmental and Regenerative Medicine (Joint fundraising appeal with Oxford University) 
£5,000,000

Infrastructure Grants  

IG/15/2/31514
Professor Andrew Trafford et al
University of Manchester
Funding towards a Nikon N-Storm Super-Resolution microscope
1 year
£265,000 

IG/15/3/31680
Professor Stefan Neubauer et al.
University of Oxford
Funding towards a new 3T MR system and installation costs 
1 year 
£1,000,000

New Horizons Grant

NH/15/1/31543                                  
Professor Mark Peters et al.
University College London (ICH)
Development of a system to characterize and provide feedback on closed chest compressions for cardiopulmonary resuscitation on paediatric wards 
2 years, 6 months 
£285,106 

Extraordinary Grants 

EX/15/1/31861                                  
Concordat Strategy Group
CRAC Limited 
Funding towards stakeholder activities to assess progress of the UK “Concordat to Support the Career Development of Researchers" 
3 years 
£13,350